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KMID : 0848120160410030105
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International Journal of Oral Biology
2016 Volume.41 No. 3 p.105 ~ p.111
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Effect of β-carotene on Cell Growth Inhibition of KB Human Oral Cancer Cells
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Yang Sung-Su
Kim Su-Gwan
Park Byung-Sun
Go Dae-San
Yu Sun-Kyoung
Kim Chun-Sung
Kim Jeong-Sun
Kim Do-Kyung
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Abstract
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β-carotene is present in carrots, pumpkins, and sweet potatoes. It suppresses many types of cancers by regulating cellular proliferation and apoptosis through a variety of mechanisms. However, the effects of β -carotene on oral cancer cells have not been clearly established. The main goal of this study was to investigate the effects of β-carotene on cell growth and apoptosis in oral cancer cells. Our results demonstrate that treatment with β-carotene induced inhibition of cell growth, and that the effect was dependent on β-carotene treatment time and concentration in KB cells. Furthermore, treatment with β-carotene induced nuclear condensation and fragmentation in KB cells. β-carotene promoted proteolytic cleavage of procaspase-3, -7, -8 and ?9 with associated increases in the concentration of cleaved caspase-3, -7, -8 and ?9. In addition, the level of cleaved PARP was increased by β-carotene treatment in KB cells. These results suggest that β-carotene can suppress cell growth and induce apoptosis in KB human oral cancer cells, and that it may have potential usefulness in anti-cancer drug discovery efforts.
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KEYWORD
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β, -carotene , cell death , apoptosis , oral cancer cells
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